原著論文 教育活動 総説国際学会研究助成


過去の研究成果(~2010)

 教 授 (2011~2013年)



----2013年-------------------------------------------------------
12.Role of reactive oxygen species in the radiation response of human hematopoietic stem/progenitor cells.
M. Yamaguchi, I. Kashiwakura.
PLos One. 2013 Jul 25;8(7):e70503.

11. Relationship between obesity and serum reactive oxygen metabolites in adolescents.
T. Kogawa and I. Kashiwakura.
Environ Health Prev Med. 2013 Nov;18(6):451-7.

10. Influence of maternal body mass index on gestational weight gain and birth weight: A comparison of parity.
T. Chiba, S. Ebina and I. Kashiwakura.
Exp Ther Med. 2013 Aug;6(2):293-298.

9. Proliferation and differentiation and maturation pathway derived from human hematopoietic stem/progenitor cells exposed to low-dose irradiation.
M. Yamaguchi, S. Ebina and I. Kashiwakura.
Radiat Emerg Med. in press.

8. Mitochondrial superoxide production and redox status in human monocytic cells after ionizing irradiation.
H. Yoshino, T. Kiminarita, Y. Matsushita and I. Kashiwakura.
Radiat Emerg Med. in press.

7. Characteristics of myeloid differentiation and maturation pathway derived from human hematopoietic stem cells exposed to different linear energy transfer radiation types.
S. Monzen, H. Yoshino, K. Kasai-Eguchi and I. Kashiwakura.
PLos One. 2013;8(3):e59385.

6. Effects of radiation on the maturation of megakaryocytes.
H. Hirose, S. Monzen, H. Yoshino, H. Sato, M. Aoki, Y. Hatayama, H. Kawaguchi, M. Sato, Y. Narita, Y. Takai and I. Kashiwakura.
J Radiat Res. 2013 May;54(3):447-52.

5. 医学部保健学科における医療情報リテラシーの理解度調査―4年間の継続調査から見た考察―.
門前暁、松谷秀哉、柏倉幾郎.
日本放射線技術学会雑誌,69(1): 33-40 (2013)
A continuous 4-year evaluation of medical informatics education in a graduate school of health sciences using a questionnaire survey.
S. Monzen,, H. Matsutani and I. Kashiwakura.
Nihon Hoshasen Gijutsu Gakkai Zasshi. 69(1): 33-40 (2013).

4. A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in a human non-small cell lung cancer A549 cell line.
T. Wakasaya, H. Yoshino, Y. Fukushi, A. Yoshizawa and I. Kashiwakura.
Int J Oncol. 42(4): 1205-1211 (2013).

3. Radiosensitivity of human hematopoietic stem/progenitor cells.
K. Kato, A. Omori and I. Kashiwakura.
J Radiat Protec. 33(1): 71-80 (2013).

2. Relationships between feeding modes and infant weight gain in the first months of life.
S. Ebina and I. Kashiwakura.
Exp Ther Med. 5(1): 28-32 (2013).

1. Involvement of placental/umibilical cord blood acid-base status and gas values on the radiosensitivity of human fetal/neonatal hematopoietic stem/progenitor cells.
M. Yamaguchi, S. Ebina and I. Kashiwakura.
J Radiat Res. 54(2): 277-284 (2013).



-----2012年-------------------------------------------------------
13. Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate.
K. Hirose, S. onzen, H. Sato, M. Sato, M. Aoki, Y. Hatayama, H. Kawaguchi, Y. Narita, Y. Takai and I. Kashiwakura.
J Radiat Res. in press.

12. Thyroid doses for evacuees from the Fukushima nuclear accident.
S. Tokonami, M. Hosoda, A. Sorimachi, I. Kashiwakura and S. Akiba.
Sci Rep. 2: 507 (2012).

11. The radioprotection effects of (-)-epigallocatechin-3-gallate on the human erythrocyte/granulocyte lineages.
S. Monzeni and I. Kashiwakura.
Radiat Prot Dosi. 152(1-3): 224-228 (2012).

10. Response of the Nrf2 protection system in human monocytic cells after ionising irradiation.
H. Yoshino, K. Kiminarita Y. Matsushita and I. Kashiwakura.
Radiat Prot Dosi. 152(1-3): 104-108 (2012).

9. Relationships between 8-hydroxy-deoxyguanosine levels in placental /umbilical cord blood and maternal/neonatal obsteric factors.
S. Ebina, T. Chiba, T. Ozaki and I. Kashiwakura.
Exp Ther Med. 4(3): 387-390 (2012).

8. Impairement of mature dendritic cells derived from X-irradiated human monocytes depends on the type of maturation stimulus used.
H. Yoshino and I. Kashiwakura.
Radiat Res. 2012 Aug 10 [Epub ahead of print].

7. Influence of breast-feeding on maternal blood pressure at one month postpartum.
S. Ebina and I. Kashiwakura.
Int J Womens Health. 4: 333-339 (2012).

6. Functional properties of synthetic N-acyl-L-homoserine lactone analogs of quorum-sensing gram-negative bacteria on the growth of human tongue cancer SAS.
H. Chai, M. Hazawa, J. Igarashi, Y. Hosokawa, H. Suga and I. Kashiwakura.
Biol Pharm Bull. 35(8): 1257-1263 (2012).

5. Regulation of the DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cell.
M. Hazawa, Y. Hosokawa, S. Monzen, H. Yoshino and I. Kashiwakura.
Oncol Rep. 28(1): 55-61 (2012).


4. Identification of up-regulated and down-regulated cis-natural antisense transcripts in the human B lymphoblastic cell line IM-9 after X-ray irradiation.
M. Chiba, T. Miura, K. Kasai, S. Monzeni, I. Kashiwakura, H. Yasue and T. Nakamura.
Mol Med Report. 5(5):1151-1157(2012).

3. Suppressive effects of liquid crystal compounds on the growth of U937 human leukemic monocyte lymphoma cells.
J. Ishikawa, Y. Takahashi, M. Hazawa, Y. Fukushi, A. Yoshizawa and I. Kashiwakura.
Cancer Cell Int. 12(1): 3 (2012).


2. Involvement of intracellular reactive oxygen species and mitochondoria in the radiosensitivity of human hematopoietic stem cells.
Y. Kaneyuki, H. Yoshino and I. Kashiwakura.

J Radiat Res, 53(1):145-150 (2012).

1. Promoting activity of the Aconitum C20-diterpenoid alkaloid derivatives on the growth of human hematopoietic stem/progenitor cells.
M. Hazawa, K. Wada and I. Kashiwakura.
Phytother Res,
26(8):1262-1264 (2012).


-----2011年-------------------------------------------------------
16. The effects of maternal exprosure to radiation on the fatus.
S. Ebina, Y. Maria and I. Kashiwakura.
Radiat Emerg Med, 1(1-2): 14-20 (2012).

15. Characteristics of reactive oxygen metabolites in the serum of early teenagers in Japan.
T. Kogawa, M. Nishimura, S. Kurauchi and I. Kashiwakura.
Environ Health Prev Med, 2011 Dec 30 [pub ahead of print].

14. Can umbilical arterial pH be a predictor of the yield of mononuclear and and CD34+ cells found in placental/umbilical cord blood at full-term vaginal delivery?
S. Ebina, A. Omori and I. Kashiwakura.
J Health Sci Res, 2: 1-8 (2012).

13. Influence of umbilical cord blood acid-base status and gas values on the yield of mononuclear cells and CD34+ cells.
S. Ebina, A. Omori, A. Tarakida, T. Ogasawara, M. Manabe, S. Katagiri and I. Kashiwakura.
J Obstet Gynecol Res, 38(7):997-1003 (2012)

12. Quality-assessment of the characteristics of placental/umbilical cord blood associated with maternal age- and parity-related factor.
A. Omori, M. Hirai, T. Chiba, K. Takahashi, S. Yamaguchi, T.A. Takahashi and I. Kashiwakura.
Transfus Apher Sci, 46(1):7-13 (2012).

11. Individual radiation exposure dose due to support activities at safe shelters in Fukushima Prefecture.
S. Monzen, M. Hosoda, M. Osanai, H. Yoshino, S. Tokonami, Y. Hosokawa, M.A. Yoshida, M. Yamada, Y. Asari, K. Satoh and I. Kashiwakura.
PLos ONE, 6(11): e27761.

10. Effect of ionizing radiation on differentiation of mouse induced pluripotent stem cells into the three germ layers.
N. Hayashi, S. Monzen, K. Ito, T. Fujioka, Y. Nakamura and I. Kashiwakura.
J Radiat Res, 53(2):195-201(2012).

9. The potential of patients' peripheral blood mononuclear cells to differentiate into dendiritc cells after hematopoietic stem cell transplantation.
H. Yoshino, N. Watanabe, K. Takahashi, K. Ogura, T. Akagi, K. Kubo and I. Kashiwakura.
Life Sci, 89(25-26):946-955.

8. Megakaryocytopoiesis and thrombopoiesis in hematopoietic stem cells exposed to ionizing radiation.
S. Monzen, E. Tashiro and I. Kashiwakura.
Radiat Res, 176(6):716-724 (2011).

7. The time variation of dose rate artificially increased by the Fukushima nuclear crisis.
M. Hosoda, S. Tokonami, A. Sorimachi, S. Monzen, M. Osanai, M. Yamada, I. Kashiwakura and S. Akiba.
Scientific Reports, 1:8(2011).

6. Terminal maturation of megakaryocytes and platelet production by hematopoietic stem cells irradiated with heavy-ion beams.
S. Monzen, K. Takahashi, H. Yoshino, K. Kasai-Eguchi and I. Kashiwakura.
Radiat Res, 176(1):8-16(2011).

5. (-)-Epigallocatechin-3-O-gallate induces nonapoptotic cell death in leukemia cells independent of the 67 kDa laminin receptor.
M. Hazawa, K. Takahashi, S. Sugata and I. Kashiwakura.
J Nat Prod, 74(4):695-700 (2011).

4. The infuluence of geneder- and age-related differences in the radiosensitivity of hematopoietic progenitor cells detected in steady-state human peripheral blood.
K. Kato, M. Kuwabara and I. Kashiwakura.
J Radiat Res, 52(3):293-299 (2011)

3. Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562.
M. Hazawa, M. Kudo, T. Iwata, K. Saito, K. Takahashi, J. Igarashi, H. Suga and I. Kashiwakura.
Invest New Drugs, 30(3):862-869 (2012).

2. Ascorbic acid enhanced apoptosis of human leukemia HL60 cells on radiation.
K. Shinozaki, Y. Hosokawa, I. Kashiwakura, K. Okumura, T. Kaku, and E. Nakayama.
J Radiat Res, 52(2):229-237(2011).

1. Supramolecular assembly composed of different mesogenic compounds possessing a w-hydroxyalkyl unit exhibits suppressive effects on the A549 human lung cancer cell line.
Y. Takahashi, M. Hazawa, K. Takahashi, M. Sagisaka, I. Kashiwakura and A. Yoshizawa.
Med Chem Comm, 2: 55-59 (2011).



教育活動


1.
保健学科の医療情報学教育における理解度調査(第3報).
横田潤児,大場久照,松谷秀哉,渋谷博,門前暁,柏倉幾郎.
弘前大学大学院保健学研究科紀要.9, 135-142 (2010).



 教 授


-----2011年-------------------------------------------------------

1.
The effects of ionizing radiation on pattern recognition receptors.
H. Yoshino and I. Kashiwakura.
14th International Congress of Radiation Research, August 28- September 1, 2011, Warsawa, Poland.
ABSTRACT, POS05-19.

2.
Time variation of ambient dose rate artificially increased by the Fukushima Dai-ichi nuclear power station aciciden.
M. Hosoda, S. Tokonami, A. Sorimachi, S. Monzen, M. Osanai, M. Yamada, I. Kashiwakura and S. Akiba.
14th International Congress of Radiation Research, August 28- September 1, 2011, Warsawa, Poland.
ABSTRACT, POS19-04.

3.
Characterisitic analysis of megakaryocytopoiesis and thrombopoiesis by hematopoietic stem cells exposed to ionizing radiation.
S. Monzen, T. Nakamura and I. Kashiwakura.
14th International Congress of Radiation Research, August 28- September 1, 2011, Warsawa, Poland.
ABSTRACT, POS25-11

4.
Ascorbic acid enhanced apoptosis of human leukemia HL60 cells on radiation.
Y. Hosokawa, S. Monzen and I. Kashiwakura.
14th International Congress of Radiation Research, August 28- September 1, 2011, Warsawa, Poland.
ABSTRACT, POS39-10

5.
The impact of repeat stereotactic radiosurgery on the management of brain metastasis with maintaining brain function.
Y. Mariya, G. Sekizawa, Y. Matsuoka and I. Kashiwakura
14th International Congress of Radiation Research, August 28- September 1, 2011, Warsawa, Poland.
ABSTRACT, POS39-17

6.
The characteristics of reactive oxygen metabolites detected in the serum of early Japanese teenagers. (P1-196)
T. Kogawa, S. Kurauchi, M. Nishimura and I. Kashiwakura.
J Epidemiol Community Health, 2011;65:A120.


7.
Effect of umbilical cord blood acid-base status and gas values on the yield of mononuclear cells and cd34 cells.(SP6-28)
S. Ebina, A. Omori, A. Tarakida, T. Ogasawara, M. Manabe, S.I. Katagiri and I. Kashiwakura.
J Epidemiol Community Health, 2011;65:A462.


 教 授


1. 科学研究費補助金 基盤研究(B) (平成25年度~28年度)
「トロンボポエチン受容体作動薬による放射曝露個体の救命効果と作用機序解明」
(研究代表者:柏倉幾郎)


2. 科学研究費補助金 若手研究(B) (平成25年度~27年度)
「がんラジオアイソトープ内用療法開始患者の治療予備能力を予測する因子の解明」
(研究代表者:門前暁)

3. 科学研究費補助金 若手研究(B) (平成25年度~26年度)
「パターン認識受容体に着目したがん放射線治療の有効性向上」
(研究代表者:吉野浩教)

4. 科学研究費補助金 挑戦的萌芽研究 (平成24年度~25年度)
「国内承認医薬品に新たな急性放射線障害治療プロトコールを見出す!」
(研究代表者:柏倉幾郎)

5. 平成24年度 弘前大学機関研究採択
「東日本大震災対応放射線科学研究プログラム」
(研究代表者:柏倉幾郎)

6. 科学技術戦略推進費(平成22~26年度)
地域再生人材創出拠点の形成「被ばく医療プロフェッショナル育成計画」



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